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双相情感障碍认知功能的长期过程:一项为期十年的随访研究
Camilla Bärthel Flaaten1,2, Ingrid Melle1, Thomas Bjella1
1Division of Mental Health and Addiction, NORMENT, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Bipolar disorders
|June 25, 2023
概括
双相情感障碍 (BD) 的认知障碍在10年内显示出长期稳定性或改善,与健康对照 (HC) 平行. 这些发现挑战了BD中的神经进展假设.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知心理学 认知心理学
背景情况:
- 在双相情感障碍 (BD) 中,认知障碍很普遍.
- 在BD中,长期的认知轨迹,特别是从早期治疗阶段开始,是研究不足的.
- 了解认知变化可以阐明BD的病理生理过程和疾病结果.
研究的目的:
- 与健康对照组 (HC) 相比,研究双相情感障碍 (BD) 患者的10年认知过程.
- 为了检查临床症状对BD认知轨迹的十年影响.
- 评估从BD的第一个治疗开始的纵向认知变化.
主要方法:
- 长度研究涉及56名BD参与者和108名HC,在基线和10年后续评估.
- 用线性混合模型分析评估八个领域的认知功能和复合得分.
- 相关性分析探索了认知得分与抑郁,躁狂和精神病症状之间的关系.
主要成果:
- 在大多数认知领域,BD参与者表现低于HC,但不包括心理速度和口语流性.
- 在BD和HC组的口头学习/记忆和口头流利方面观察到认知改善.
- 短期记忆,思维速度,精神运动速度和工作记忆在两组10年内都保持稳定.
结论:
- 在双相情感障碍 (BD) 中,长期认知功能从第一个治疗年到10年的随访期间表现出稳定性或改善.
- 尽管最初的损伤,在BD认知变化的模式平行健康的对照 (HC).
- 这些纵向发现不支持双相情感障碍中渐进性神经退行 (神经进展) 的概念.
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