在蛋白质组学中进行大规模单向ANOVA测试后对错误发现进行控制:实际考虑

One-way ANOVA analyzes more than three samples categorized by one factor. For example, it can compare the average mileage of sports bikes. Here, the data is categorized by one factor - the company. However, one-way ANOVA cannot be used to simultaneously compare the sample mean of three or more samples categorized by two factors. An example of two factors would be sports bikes from different companies driven in different terrains, such as a desert or snowy landscape. Here, two-way ANOVA is used...

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...

One-Way ANOVA can be performed on three or more samples with equal or unequal sample sizes. When one-way ANOVA is performed on two datasets with samples of equal sizes, it can be easily observed that the computed F statistic is highly sensitive to the sample mean.
Different sample means can result in different values for the variance estimate: variance between samples. This is because the variance between samples is calculated as the product of the sample size and the variance between the...

Analysis of Variance, or ANOVA, is a powerful statistical technique used to analyze parametric data, primarily in research and experimental studies. It's designed to compare the means of two or more groups, assisting researchers in identifying any significant differences between these group means. There are two main types of ANOVA based on the complexity of the analysis: one-way and two-way.
One-way ANOVA is applied when a single independent variable or factor is scrutinized. It compares...

The Bonferroni test is a statistical test named after Carlo Emilio Bonferroni, an Italian mathematician best known for Bonferroni inequalities. This statistical test is a type of multiple comparison test to determine which means are different than the rest. Bonferroni test can minimize the Type 1 error by reducing the significance level alpha, which otherwise increases with sample pairs.
The means of different samples are first paired in all possible combinations.
The null hypothesis of the...

The two-way ANOVA is an extension of the one-way ANOVA. It is a statistical test performed on three or more samples categorized by two factors - a row factor and a column factor. Ronald Fischer mentioned it in 1925 in his book 'Statistical Methods for Researchers.'
The two-way ANOVA analysis initially begins by stating the null hypothesis that there is an interaction effect between the two factors of a dataset. This effect can be visualized using line segments formed by joining the...