白质超强度作为血管对AT的贡献 (N) 框架
1A/Prof. Ng Kok Pin, Senior Consultant, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore 308433, Tel: +65 63577153,
The journal of prevention of Alzheimer's disease
|June 25, 2023
概括
在AT(N) 框架分类阿尔茨海默病 (AD) 的进展使用粉样蛋白-β,,和神经退行生物标志物. 白质超强度 (WMH) 显示与粉样β混合的关联,需要进一步研究在AD的病理.
科学领域:
- 神经学 神经学
- 生物标志物 生物标志物
- 神经退行性疾病 神经退行性疾病
背景情况:
- 在AT(N) 框架下,阿尔茨海默病 (AD) 通过氨基酸β (Aβ), (T) 和神经退行 (N) 生物标志物在生物学上进行了阿尔茨海默病 (AD) 的分期.
- 脑血管疾病 (CVD),特别是来自慢性缺血的白质过强度 (WMH),与AD病因相关.
- 没有完全理解WMH和AD核心Aβ和tau病理之间的关系.
结论:
- 在AD的AT(N) 框架内,WMH可以作为血管生物标志物.
- 对新型心血管疾病生物标志物的进一步调查可能会揭示心血管疾病对AD的贡献.
- 需要协调的方法来验证WMH在ATN分类中的作用.
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