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聚焦超声波:一种用于改善高风险HPV感染患者的阴道微生态的新疗法

Hua Tao^1,2, Dingyuan Zeng^1,2, Wenzhi Chen¹

¹State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group

|June 25, 2023

概括

聚焦超声波 (FU) 治疗有效改善高风险人类乳头瘤病毒 (HR-HPV) 感染的女性的阴道微生态. 与抗生素结合的FU有助于急性阴道炎患者的康复,恢复正常的阴道菌群并减少HPV阳性.

科学领域:

妇科瘤学妇科瘤学
微生物学微生物学
医学超声波医学超声波

背景情况:

高风险的人类乳头瘤病毒 (HR-HPV) 感染是宫癌的重要危险因素.
阴道微生态在维持生殖健康和影响HPV清除方面发挥着至关重要的作用.
聚焦超声波 (FU) 是宫HR-HPV感染的新兴治疗方式.

研究的目的:

评估聚焦超声波 (FU) 治疗对被诊断患有HR-HPV感染的女性阴道微生态的影响.
评估FU在与急性阴道炎和HR-HPV患者的抗生素治疗结合的疗效.

主要方法:

从169名宫HR-HPV感染的妇女收集了阴道分泌物,在FU治疗前和3个月后.
在101名急性阴道炎患者中,在一周的抗生素治疗后也收集了分泌物.
分析了阴道微生态参数,包括植物多样性,乳酸菌比例 (H2O2负率) 和阴道炎指标.

主要成果:

在3个月内,FU治疗显著增加了正常的阴道菌群率,从40.3%增加到93.5% (p<0.01).
在FU后的H2O2阴性率,白细胞化酶,化酶,细菌性,真菌性和三性阴道炎率 (p<0.01) 中观察到显著改善.
在FU后正常化阴道微生态的患者中,HPV阳性率明显较低,特别是那些治疗前和治疗后都具有正常微生态的患者 (p<0.01).

结论:

聚焦超声波 (FU) 是对宫HR-HPV感染的有效治疗方法,促进恢复正常的阴道微生态.
在HR-HPV阳性患者中,FU不会对阴道微生态产生负面影响,这些患者最初的菌群正常.
结合FU和抗生素治疗有助于改善急性阴道炎的HR-HPV阳性患者的阴道微生态,支持Lactobacillus功能.

关键词:

聚焦式超声波的使用方法在HR-HPV感染中.宫的子宫可以阴道微生态阴道微生态

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