较高的D-二分体和激活的部分血栓形成时间是患有腹膜透析相关腹膜炎的患者的不良预后因素
Ya-Juan Huang1, Li-Ping Xiong1, Xing Zhang1
1Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
概括
延长的活性部分血栓形成时间 (APTT) 和高的D-二次体 (DD) 水平与腹膜透析相关腹膜炎 (PDRP) 患者的治疗失败有关. 这些凝血标志物表明PDRP结果的风险更高.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
背景情况:
- 凝血系统功能障碍与腹膜透析 (PD) 和细菌感染的不良结果有关.
- 腹膜透析相关腹膜炎 (PDRP) 是一个常见的并发症,具有重大治疗挑战.
研究的目的:
- 调查凝血参数与PDRP治疗失败之间的关联.
- 为了确定预测PDRP治疗结果的特定凝血标志物.
主要方法:
- 对PDRP患者记录 (年龄≥18岁) 的回顾性分析.
- 基于激活的部分血栓形成时间 (APTT) 和D-二分体 (DD) 水平的PDRP发作分类.
- 后勤回归分析以确定APTT,DD和PDRP治疗失败之间的关联.
主要成果:
- 在110例PDRP发作中,有30例出现治疗失败.
- 长时间的APTT与PDRP治疗失败有显著的关联 (OR = 1.166,p = 0.004).
- 高的DD水平也与PDRP治疗失败有显著的关联 (OR = 1.374,p = 0.017).
结论:
- 延长的基线APTT和升高的DD水平是导致PDRP治疗失败的独立风险因素.
- 这些凝血标记可能有助于预测PDRP治疗结果.
- 了解这些关联可以为PDRP的临床管理策略提供信息.
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