在儿童中微RNA的评估
Kürşat Bora Çarman1, Hande Gazeteci Tekin2, Dilek Çavuşoğlu3
1Department of Pediatric Neurology, Eskişehir Osmangazi University Faculty of Medicine, Eskişehir, Turkey.
Turkish archives of pediatrics
|June 26, 2023
概括
在患有的儿童中,血清中microRNA-155和microRNA-223水平升高,特别是在耐药病例中. 增加的microRNA-155和减少的microRNA-146a与风险有关.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 生物化学 生物化学
背景情况:
- 的病理生理学还没有完全被理解.
- 在成年中观察到微RNA (miRNA) 表达变化.
- 在儿童中调查miRNA至关重要.
研究的目的:
- 为了识别患有特异性普遍性的儿童的血清microRNA表达差异.
- 为了比较药物反应和药物耐药群体之间的miRNA资料.
主要方法:
- 分析了43名患有的儿童和66名对照儿童的血清样本.
- 使用定量实时聚合酶链反应 (qRT-PCR) 来测量微RNA-181a,微RNA-155,微RNA-146a和微RNA-223.
- 包括患有异常性泛性和正常MRI的患者.
主要成果:
- 与对照组相比,儿童的血清microRNA-155和microRNA-223表达显著增加.
- 与药物耐药性患者相比,耐药性患者的microRNA-146a,microRNA-155和microRNA-223水平较高.
- 后勤回归表明microRNA-155增加作为风险因素,microRNA-146a减少作为风险因素.
结论:
- 儿童与血清微RNA表达异常有关.
- 特定的微RNAs (miR-155,miR-223,miR-146a) 在儿科中显示出改变的表达模式.
- 这些发现有助于理解miRNA在儿童发育中的作用.
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