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在粒状前列腺炎中强烈的PD-L1表达.

Dorian Dikov1,2, Maria Koleva1, Angelina Mollova1

  • 1Department of General and Clinical Pathology, Medical University of Plovdiv, Plovdiv, Bulgaria.

The Prostate
|June 26, 2023
PubMed
概括

编程细胞死亡连接蛋白 (PD-L1) 在粒状前列腺炎 (GP) 中表达强烈,有助于诊断. 这一发现有助于识别前列腺组织中的粒状炎症,提高了这种疾病的诊断准确性.

关键词:
在PD-L1中.这种癌症是癌症癌症.有颗粒性前列腺炎的前列腺炎.淋巴细胞上皮质病变的病变在前列腺炎前列腺炎.

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科学领域:

  • 泌尿器科 泌尿器科 泌尿器科 泌尿器科
  • 免疫学 免疫学 免疫学
  • 病理学 病理学 病理学

背景情况:

  • 编程细胞死亡配体蛋白 (PD-L1) 表达在非瘤和炎症性前列腺疾病中未得到研究.
  • 仅使用常规组织学来诊断颗粒性前列腺炎 (GP) 可能具有挑战性.
  • 在GP中PD-L1表达尚未得到广泛的研究.

研究的目的:

  • 在各种形式的粒状前列腺炎 (GP) 中研究PD-L1表达.
  • 评估PD-L1作为GP的诊断标记物的实用性.
  • 将GP中的PD-L1表达与控制前列腺组织进行比较.

主要方法:

  • 研究了17例GP的PD-L1表达,包括非特异性GP,BCG诱导的前列腺炎,结核病和术后颗粒瘤.
  • 利用了来自前列腺腺癌 (PCa) 和高度组织前列腺炎 (HG-HP) 患者的10个激进前列腺切除术的对照组.

主要成果:

  • 所有GP病例都在粒状炎症中表现出强烈,易于看到的膜性PD-L1表达.
  • 包括HG-HP和PCa组织在内的对照病例,在炎症透物,瘤围体或侧膜中没有显著的PD-L1表达.

结论:

  • 这项研究是第一个在粒状前列腺炎 (GP) 中检查PD-L1表达的研究.
  • PD-L1染色有效地识别了GP中的颗粒状炎症,这表明其作为诊断辅助的实用性.