通过基于传统医学知识的方法平台,发现抗癌植物化学 rutin 抗乳腺癌
Jungwhoi Lee1, Jungsul Lee2, WooGwang Sim3
1Department of Biotechnology, College of Applied Life Science, Jeju National University, Jeju 63243, Korea.
BMB reports
|June 26, 2023
概括
这项研究开发了一个平台,使用传统文本和虚拟查来寻找基于植物的乳腺癌药物. 鲁丁被确定并验证为一种阻断EGFR信号传递的化合物,在体外和体内表现出抗癌作用.
科学领域:
- 植物化学 植物化学
- 药理学 药理学是指药理学的学科.
- 计算生物学 计算生物学
背景情况:
- 传统医学文本为发现新型治疗化合物提供了丰富的来源.
- 开发系统的平台对于有效地识别和验证植物制药的潜在药物至关重要.
- 乳腺癌仍然是一个重大的全球健康挑战,需要创新的治疗策略.
研究的目的:
- 建立一个系统的平台,从传统医学文本中识别抗乳腺癌的化合物.
- 用计算和实验方法验证已识别的化合物的疗效.
主要方法:
- 传统医学文献的文本挖掘,以识别植物化学物质.
- 3D虚拟对接选用于预测化合物相互作用.
- 在体外和体内实验验以验证抗癌效应.
主要成果:
- 鲁丁被确定为一种传统用于癌症的植物化学物质.
- 虚拟查预测了 rutin 阻断表皮生长因子受体 (EGFR) 信号通路的能力.
- 鲁丁通过 in vitro 抑制 EGFR 信号传递,对乳腺癌细胞产生显著的抗癌作用.
- 在体内模型中,鲁丁在预防乳腺癌复发方面表现出有效性.
结论:
- 文本挖掘,虚拟选和实验验证的综合方法对于发现新型植物化学化合物是有效的.
- 鲁是开发针对恶性瘤,包括乳腺癌的新疗法的一个有前途的候选人.
- 这个平台有助于发现用于向癌症治疗的植物性化合物.
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