相关实验视频

Updated: Jul 25, 2025

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Published on: October 3, 2018

随着多发性骨髓瘤的博特佐米布,莱纳利多米德和德克萨米他诱导后,外周血液干细胞的调动:一个真实世界的单中心体验

Shirlene Sim¹, Hang Quach¹, Tina Pham²

¹Clinical Haematology, St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia.

Internal medicine journal

|June 26, 2023

概括

针对多发性骨髓瘤的基于莱纳利多米德的VRd诱导疗法可能会影响干细胞的采集. 将G-CSF与循环胺结合使用,可以改善外周血干细胞 (PBSC) 产量,用于VRd后的自身干细胞移植 (ASCT).

科学领域:

血液学血液学血液学
在瘤学瘤学.
干细胞移植干细胞移植

背景情况:

博尔特佐米布,莱纳利多米德和德克萨米松 (VRd) 是目前适用于移植的多发性骨髓瘤的标准诱导疗法.
列纳利多米德的骨髓抑制作用可能会降低外周血液干细胞 (PBSC) 的产量.
环胺已被用于增强PBSC动员.

研究的目的:

评估莱纳利多米德对PBSC动员的影响.
确定VRd诱导疗法后的最佳动员策略.

主要方法:

对56名接受PBSC调动的多发性骨髓瘤患者的回顾性审查.
三个队列的比较:仅使用G-CSF的VCD,使用G-CSF和环胺 (G-CSF + Cyclo) 的VRd,仅使用G-CSF的VRd.
分析CD34+细胞计数和自主干细胞移植 (ASCT) 采集成功率.

主要成果:

仅接受G-CSF的VCD和VRd组之间的平均CD34+计数没有显著差异.
与单独使用G-CSF相比,使用G-CSF+Cyclo调动的VRd患者的CD34+平均计数显著高于单独使用G-CSF (8.89与5.50×10^6/kg相比,P=0.04).
在接受G-CSF + Cyclo治疗的VRd患者中,95%的患者收集了足够的细胞进行≥2个ASCT,而仅接受G-CSF治疗的患者中,这一比例为62%.

结论:

在使用G-CSF单独进行三次VRd循环后,至少可以实现一个ASCT的成功PBSC调动.
基于环胺的动员策略对VRd诱导的患者有益,因为他们需要足够的干细胞来进行两个或两个以上的ASCT.

关键词:

环酸胺的使用方法颗粒细胞殖民地刺激因子莱纳利多胺的使用方法多发性骨髓瘤是多发性骨髓瘤的一种.周围血液干细胞调动

更多相关视频

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

Published on: July 15, 2015

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis

Published on: December 8, 2023

相关概念视频

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...

Differentiation of Common Myeloid Progenitor Cells

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...