使用当代指南对明显抗性高血压患者的表征:来自CV-QUIC的见解
Joseph E Ebinger1, Ty J Gluckman2, Jose Magraner1
1Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (J.E.E., J.M.).
Hypertension (Dallas, Tex. : 1979)
|June 26, 2023
概括
明显耐药性高血压 (aRH) 影响8.5%的高血压患者,通常有更多的并发症. 控制的aRH患者更频繁地接受矿物质皮质醇受体抗剂,这表明改善了护理机会.
科学领域:
- 心脏病学 心脏病学
- 高血压研究 高血压研究
- 临床药理学 临床药理学
背景情况:
- 明显抗性高血压 (aRH) 与心血管风险增加有关.
- 目前对aRH患者特征和治疗模式的理解是有限的.
- 当代美国高血压指南定义了ARH标准.
研究的目的:
- 根据当前的指导方针评估aRH的患病率.
- 描述ARH患者的临床特征.
- 分析ARH患者的药物治疗模式.
主要方法:
- 根据当代高血压指南对3个医疗保健系统的患者进行分类.
- 描述了ARH患者的人口统计和临床特征.
- 在aRH和非aRH患者之间,以及在受控和不受控制的aRH之间,比较特征.
主要成果:
- 分析了2,420,468名患者;55.6%是高血压患者,其中8.5%符合aRH标准.
- aRH患者患糖尿病和心力衰竭等并发病率较高.
- 控制的aRH患者更经常被处方β-阻断剂,利尿剂,酸盐和矿物质皮质类受体对抗剂.
结论:
- 观察到ARH患病率 (8.5%) 比之前报告的更低.
- aRH患者表现出显著的并发症负担.
- 药物使用的差异,特别是矿物质皮质类受体对抗剂,突出了减少心血管风险的潜在护理改善策略.
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