碳氨基化和氨基化:氧胺的C-H功能化
Tanmayee Nanda1,2, Shubham Kumar Dhal1,2, Gopal Krushna Das Adhikari1,2
1School of Chemical Sciences, National Institute of Science Education and Research (NISER), Bhubaneswar, Odisha 752050, India. pcr@niser.ac.in.
这项研究引入了一种新型的催化脱氧化马莱胺的碳胺化,使用氧胺作为氨基源. 它还介绍了一种C-H化方法,通过无痕指导组策略成功安装了maleimide组.
科学领域:
- 有机化学 有机化学
- 催化剂是一种催化剂.
- 合成方法论 合成方法论
背景情况:
- 传统的碳氨基化方法往往缺乏效率,需要恶劣的条件.
- 在有机合成中,开发新的合成路径来功能化烯和芳香化合物至关重要.
- 马利米德是药物化学和材料科学中重要的构建模块.
研究的目的:
- 开发一种新型的催化脱氧化碳酸胺的olefins.
- 为了实现有史以来第一个脱式碳胺的maleimides.
- 为了建立一个C-H的olefination协议,用于phenoxyacetamide的ortho功能化.
主要方法:
- 催化反应利用氧胺作为氨基化和指导源.
- olefins的脱氧化碳氨基化,保持双键.
- 基辅助的E2消除机制用于C-H油脂化.
主要成果:
- 成功证明了罗催化烯酸的碳氨基化.
- 首次实现了maleimides的脱式碳氨基化.
- 开发了一种高效的C-Holefination协议,将maleimide安装在phenoxyacetamide的正向位置上.
结论:
- 氧胺作为一个有效的aminating来源在脱氧化carboamination.
- 开发的C-H化协议使用氧胺作为无痕指导组.
- 这项研究扩大了催化转换的范围,并提供了新的合成途径.
更多相关视频
06:34Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS
Published on: June 20, 2014
10:42Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
相关概念视频
Reactions of α-Halocarbonyl Compounds: Nucleophilic Substitution
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3
Conjugate Addition to α,β-Unsaturated Carbonyl Compounds
Acid-Catalyzed α-Halogenation of Aldehydes and Ketones
In the first step of the mechanism, the acid protonates the carbonyl oxygen resulting in a resonance-stabilized cation, which subsequently loses an α-hydrogen to form an enol tautomer. The C=C bond in an enol is highly nucleophilic because of the electron-donating nature of the –OH group. Consequently, the double bond attacks an electrophilic halogen to form a...
Nucleophilic Acyl Substitution of Carboxylic Acid Derivatives
Preparation of Carboxylic Acids: Hydrolysis of Nitriles
