类作为"更好的生物标志物"? 价值,挑战和潜在的解决方案,以促进实施实施
Agnieszka Latosinska1, Maria Frantzi1, Justyna Siwy1
1Department of Biomarker Research, Mosaiques Diagnostics GmbH, Hannover, Germany.
Mass spectrometry reviews
|June 26, 2023
概括
体液中的原生显示出作为临床生物标志物的前景. 质谱学在这个领域取得了进展,但样本规模小,验证不足等挑战阻碍了改善患者护理的广泛实施.
科学领域:
- 生物化学 生物化学
- 蛋白质组学是指蛋白质组学.
- 临床化学 临床化学
背景情况:
- 酸在生理和病理生理过程中起着至关重要的作用.
- 身体液体 (尿液,血液,脑脊液) 中的内源性可用于分析.
- 类正在成为有价值的临床生物标志物.
研究的目的:
- 审查最近关于对体液中本地的基于质谱的研究的文献.
- 专注于体生物标志物的应用,以加强临床管理.
- 批判性地评估生物标记物的临床实用性,实施状态,挑战和解决方案.
主要方法:
- 在过去5年内发表的研究文献综述.
- 专注于基于质谱的平台,用于内源性分析.
- 重点是研究应用类作为临床实用生物标志物的研究.
主要成果:
- 使用质谱测量用于内源性生物标志物评估的研究显著增加.
- 在患者管理和临床试验中的少数成功实施表明了现场演变.
- 大多数研究缺乏足够的样本规模和验证,造成发现-实施差距.
结论:
- 质谱法越来越多地用于生物标记物的发现.
- 类生物标志物的领域正在进步,有一些成功的临床应用.
- 克服与样本大小和验证相关的挑战对于临床实施至关重要.
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