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Essential Components of Borreliella Borrelia burgdorferi In Vitro Transcription Assays

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生态相互作用推动了两种传播病原体Borrelia burgdorferi和Babesia microti的种群动态

Danielle M Tufts^1,2,3, Ben Adams⁴, Maria A Diuk-Wasser³

¹Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, PA, USA.

Proceedings. Biological sciences

|June 26, 2023

概括

垂直传播显著影响白足小鼠中Borrelia burgdorferi (Bb) 和Babesia microti (Bm) 的流行率. 这一发现对于理解和控制这些传播疾病至关重要.

科学领域:

生态学和进化生物学
流行病学流行病学
数学生物学数学生物学

背景情况:

菌 (Borrelia burgdorferi) (Bb) 和小菌 (Babesia microti) (Bm) 是由传播的动物传染病原体.
这些病原体在Ixodes scapularis和Peromyscus leucopus小鼠中共同循环.
从历史上看,Bm的流行原因是传输效率和宿主范围较低.

研究的目的:

研究共感染动态和垂直传播在塑造Bb和Bm流行模式中的作用.
在P. leucopus的自然种群中阐明Bb和Bm之间的共感染动态.

主要方法:

使用了多年的,多个位置的纵向数据集.
运用数学建模来分析共感染动力学.
专注于Peromyscus leucopus作为主要的储宿主.

主要成果:

在没有垂直传输的情况下,Bb在比Bm更低的tick数下是可行的.
通过垂直传输,Bm在比Bb更低的tick数下变得可行.
垂直传播在季节早期对Bm流行有很大影响;同时感染在淋巴儿峰值期间起作用.

结论:

垂直传播是Bm流行的一个关键因素,特别是在赛季早期.
同感染动态对Bb和Bm的持久性影响有限.
未来的研究应该探索Bm垂直传播对环境因素的敏感性,以改善监测和控制.

关键词:

黑腿是一种黑腿.生态流行病学模型机械模型机械模型储水库的宿主是什么?垂直传输的垂直传输方式这是一只白脚小鼠.

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