乙辅酶A结合蛋白 (ACBP):一个与衰老和疾病相关的"自检查点"
Léa Montégut1,2,3, Mahmoud Abdellatif1,2,4,5, Omar Motiño1,2
1Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue Contre le Cancer, Inserm U1138, Université Paris Cité, Sorbonne Université, Paris, France.
Aging cell
|June 26, 2023
概括
在营养压力期间分泌的乙辅酶A结合蛋白 (ACBP/DBI) 可以通过释放自来阻止延长寿命和健康寿命. 这种蛋白质与衰老和各种疾病有关.
科学领域:
- 生物化学 生化学
- 细胞生物学 细胞生物学
- 衰老研究研究 衰老研究
背景情况:
- 乙辅酶A结合蛋白 (ACBP),也称为甘结合抑制剂 (DBI),是一种古老的蛋白质,在欧细菌和真核生物中保存.
- 在脂肪酸代谢中,ACBP/DBI在细胞内起作用,但在营养稀缺期间,也通过自细胞分泌在细胞外.
- 细胞外ACBP/DBI与多种受体相互作用,包括G蛋白合受体,丁酶和GABAA受体,影响各种生理过程.
研究的目的:
- 调查细胞外甲基辅酶A结合蛋白 (ACBP/DBI) 在营养应激反应中的作用及其对寿命和健康的影响.
- 探索 ACBP / DBI 中和影响自和其抗衰老潜力的机制.
- 检查ACBP/DBI水平与人类的衰老和各种疾病状态的关联.
主要方法:
- 在各种模型生物 (酵母菌,粘菌,线虫,小鼠) 中,基因或抗体介导的ACBP/DBI 基因组的抑制.
- 监测营养应激诱导的适应,包括化和食物摄入.
- 评估寿命和健康延长,加上自诱导分析.
- 在衰老和疾病的背景下,分析人体组织和血中ACBP/DBI水平.
主要成果:
- 抑制ACBP/DBI干扰了物种间的营养应激适应.
- 抑制ACBP/DBI显著提高了酵母,线虫和小鼠模型中的寿命和健康期.
- 寿命和健康延长效应始终与诱导自有关.
- 在老化,肥胖,感染和各种慢性疾病的人群中观察到较高的ACBP/DBI水平.
结论:
- 中和细胞外ACBP/DBI作为"自检查点抑制",释放自的抗衰老效益.
- ACBP/DBI在营养应激反应和生物体衰老中起着保留作用.
- ACBP/DBI代表了与年龄相关的疾病和与高水平相关的疾病的潜在治疗标.
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