恶性瘤和分子变化的概率,根据ThyroSeq v3基因组分类器在贝塞斯达的第四类IV类基因组分类器确定
Youley Tjendra1, Darcy A Kerr2,3, Yiqin Zuo1
1Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
Cancer cytopathology
|June 26, 2023
概括
甲状腺Seq分子测试揭示了贝塞斯达类别IV甲状腺结节中明显的分子概况. 瘤细胞毛囊瘤 (OFN) 与毛囊瘤 (FN) 相比,具有较低的恶性瘤风险和不同的变化.
科学领域:
- 内分泌学和甲状腺癌诊断 诊断 甲状腺癌
- 分子病理学和基因组分析
- 细胞病理学和风险分层.
背景情况:
- 甲状腺细针吸收细胞学 (FNAC) 往往产生不确定的结果,需要进一步的诊断工具.
- ThyroSeq分子测试有助于评估不确定的FNAC恶性瘤 (POM) 的概率.
- 贝塞斯达类别IV (BIV) 代表了一大批不确定的甲状腺结节,需要精确的风险评估.
研究的目的:
- 调查贝塞斯达类别IV (BIV) 甲状腺结节中的子类别是否与特定的分子变化相关.
- 确定BIV子类别与分子衍生恶性瘤风险 (MDROM) 之间的关联.
- 分析BIV子类别与恶性瘤 (ROM) 的整体风险之间的关系.
主要方法:
- 追溯分析92个BIV结节,包括FNAC幻灯片,ThyroSeq v3基因组分类器结果和手术后续.
- 结节被分为卵泡瘤 (FN) 具有或没有异型,以及瘤细胞卵泡瘤 (OFN).
- 分析MDROM,ROM和分子变异的频率 (RAS突变,染色体副本数变化) 在FN和OFN亚组中.
主要成果:
- 在92个BIV结节中,有46个是FN (15个有异型,31个没有),46个是OFN.
- 在BIV中,MDROM为34.3%,OFN的趋势低于FN. 在FN中,RAS突变更频繁 (p=.02),而染色体拷贝数的改变在OFN中更频繁 (p<.01).
- 组织学后续检查显示,OFN (p=.1) 与FN相比,OFN的ROM趋势较低 (p=.1). 在FN中,细胞腺瘤是最常见的OFN诊断,而不是毛囊变异的乳头甲状腺癌.
结论:
- 贝塞斯达类别IV甲状腺结节表现出基于FN和OFN分类的分别分子形状.
- 瘤细胞毛囊瘤 (OFN) 与毛囊瘤 (FN) 相比,显示出较低的分子衍生和总体恶性瘤风险的趋势.
- 在OFN和FN之间存在不同的分子变化和风险概况,支持它们独特的生物行为和临床管理.
关键词:
在BRAF G466RR中使用.贝塞斯达 (Bethesda) 是第四类的城市.在MDROM中,MDROM是MDROM.这就是POMOM的意义.ThyroSeq v3 GC GC Seq GC Seq v3 GC Seq GC Seq GC Seq v3 GC Seq GC Seq GC Seq v3 GC Seq GC Seq v3 GC Seq GC Seq v3 GC Seq v3 GC Seq v3 GC Seq v3 GC Seq v3 GC Seq v3 GC Seq v3 GC Seq v3 GC Seq v3 GC Seq v3 GC Seq v3 GC Seq v3 GC Seq v3 GC Seq v3 GC Seq v3 GC Seq v3 GC Seq v3 GC Seq v3 GC Seq v3 GC Seq v3 GC Seq v3 GC Seq v3 GC Seq v3 GC Seq v3 GC Seq v3 GC Seq v3 GC Seq v3 GC Seq v3 GC毛囊性新生体的发生.相关概念视频
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