对支气管喘的矿泉水吸入:一个元分析
Anatoliy D Fesyun1, Umberto Solimene2, Irina A Grishechkina3
1National medical research center for rehabilitation and balneology, Moscow. fad68@yandex.ru.
European journal of translational myology
|June 26, 2023
概括
吸入矿泉水对支气管喘 (BA) 管理有积极的影响. 这一元分析显示,在接受矿泉水治疗的BA患者中,肺功能得到改善,症状减少.
科学领域:
- 肺部病理学 肺部病理学
- 治疗干预 治疗干预
- 基于证据的医学基于证据的医学.
背景情况:
- 支气管喘 (BA) 是一个重要的全球健康问题,发病率和死亡率很高.
- 矿泉水吸入是一种常见但有争议的BA治疗方法.
- 相互矛盾的证据需要对BA的矿泉水吸入疗效进行全面评估.
研究的目的:
- 评估矿泉水吸入对支气管喘进展的整体有效性.
- 综合了对BA患者矿泉水治疗的随机临床研究的发现.
主要方法:
- 在多个数据库 (PubMed,EMBASE等) 中进行了系统的文献搜索. 按照PRISMA的指导方针进行.
- 对14项研究进行了元分析,其中包括2项随机对照试验,涉及525名患者.
- 随机效应模型用于计算FEV1.1等关键结果的标准化平均差异.
主要成果:
- 所有14篇审查的文章都得出结论,吸入矿泉水对BA疾病的发展有积极的影响.
- 接受矿泉水吸入的患者在强迫呼气体积 (FEV1) 中显著改善,以常态和升的百分比.
- 在治疗组中观察到心脏BA症状的频率和强度的统计显著减少.
结论:
- 矿泉水吸入是一种有益的治疗方法来治疗支气管喘.
- 该疗法在各种BA严重程度上表现出有效性,包括轻度,中度和荷尔蒙依赖病例.
- 有证据支持矿泉水吸入可以改善BA患者的肺功能和症状控制.
相关概念视频
01:25Antiasthma Drugs: β2-Adrenoceptor Agonists
317
Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...
317
01:30Asthma-IV: Diagnostic and Management
2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K
01:29Asthma-I: Introduction
2.7K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.7K
01:20Antiasthma Drugs: Muscarinic Receptor Antagonists
348
Muscarinic receptor antagonists, also known as antimuscarinic agents, are a class of bronchodilators used to treat asthma, although they are more commonly used to treat COPD. They work by inhibiting the action of acetylcholine (ACh), a neurotransmitter, on muscarinic receptors found in the airways.
Antimuscarinic agents compete with ACh for the same binding site on the muscarinic receptors. By binding to these receptors, they inhibit the downstream effects of ACh and block the parasympathetic...
Antimuscarinic agents compete with ACh for the same binding site on the muscarinic receptors. By binding to these receptors, they inhibit the downstream effects of ACh and block the parasympathetic...
348
01:17Drugs Used in Lower Respiratory Disorders: Overview
504
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
504
01:24Antiasthma Drugs: Methylxanthines
278
Theophylline, a member of the methylxanthine class of bronchodilators, has long been used in asthma management. While its exact mechanism of action is not fully understood, it is believed to have multiple effects on various cellular processes.
Theophylline is thought to inhibit phosphodiesterase enzymes, increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). This rise in cAMP and cGMP concentrations stimulates cardiac function,...
Theophylline is thought to inhibit phosphodiesterase enzymes, increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). This rise in cAMP and cGMP concentrations stimulates cardiac function,...
278