软组织肉瘤患者治疗毒性的决定因素
Katja A Schönenberger1,2, Emilie Reber1, Karin Schläppi1
1Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism (UDEM), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Nutrition and cancer
|June 26, 2023
概括
根据2002年营养风险查 (NRS) 评分评估的营养状况,显著影响软组织肉瘤患者的治疗毒性. 常规的营养评估和治疗对于优化癌症护理和患者结果至关重要.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 营养科学 营养科学
背景情况:
- 软组织肉瘤是一种罕见的恶性瘤,传统上基于患者和瘤因素进行治疗.
- 关于患者特征,特别是营养状况如何影响临床结果的数据有限.
- 治疗期间的身体成分变化对于预测毒性,结果和死亡率至关重要.
研究的目的:
- 在接受化疗的软组织肉瘤患者中,研究身体组成和治疗毒性之间的关系.
- 确定与治疗相关不良事件相关的关键患者特征.
主要方法:
- 使用SliceOmatic软件对基线和后续计算断层扫描 (CT) 的分析.
- 包括接受一线息化疗的肉瘤患者 (2017年10月 - 2020年1月).
- 使用常用术语对不良事件的标准 (CTCAE) 评估治疗毒性,并通过NRS 2002评估营养状况.
主要成果:
- 2002年营养风险查 (NRS) 评分,psoas肌肉厚度与身高的比率和并发症与整体治疗毒性有显著的关联.
- 骨肌指数和患者年龄显示出与毒性相关的强烈趋势.
- 身体成分指标是肉瘤患者化疗毒性的重要预测指标.
结论:
- 对于癌症患者,NRS 2002工具应在住院和门诊环境中例行实施.
- 营养治疗应该是多模式癌症治疗的组成部分.
- 为了个性化优化癌症治疗,需要验证的,标准化的肌肉质量量量化的方法.
相关概念视频
02:56Treatment Resistant Cancers
3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
02:50Combination Therapies and Personalized Medicine
5.0K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.0K
02:49Cancer Therapies
7.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.8K