牙周炎是否影响生物衰老与死亡率的关联?
1Department of Oral Medicine, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China.
Journal of dental research
|June 26, 2023
概括
牙周炎可能会加剧40岁以上成年人生物衰老和死亡风险之间的联系. 保持牙健康可能是减缓衰老和延长寿命的关键.
科学领域:
- 老年学是一门学科.
- 牙周病学 牙周病学
- 流行病学 流行病学
背景情况:
- 随着人口老龄化,牙周炎的患病率在全球范围内正在上升.
- 牙周炎与加速衰老和增加死亡率有关.
- 牙周炎对生物衰老和死亡率的影响需要进一步研究.
研究的目的:
- 调查牙周炎是否会改变生物衰老与全因和因特定死亡率之间的关联.
- 分析中年和老年人的这种关系.
主要方法:
- 一项全国范围的前性队列研究,使用NHANES III (n=6,272) 参与者的数据,年龄≥40.
- 现型年龄加速 (PhenoAgeAccel) 用于测量生物衰老.
- 使用CDC/AAP标准定义了中度/重度牙周炎.
- 进行了多变量考克斯回归和相互作用分析.
主要成果:
- PhenoAgeAccel的最高四分位数与全因死亡率的增加有关.
- 与没有/轻度牙周炎 (HR=1.789) 患者相比,中度/严重牙周炎 (HR=2.446) 患者的这种关联显著增强.
- 牙周状况显著改变了PhenoAgeAccel-死亡率相关性 (P=0.012),特别是在中年成人,女性和非西班牙裔白人中.
结论:
- 牙周炎可能会加剧中年和老年人生物衰老和全因死亡率之间的关联.
- 保持牙周健康可能是减轻衰老影响和促进寿命的策略.
- 进一步研究因特定原因死亡的相互作用是有必要的.
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