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在基于人口的队列中,状细胞特征与不良妊娠结果的关联

Joseph Hulsizer¹, Andrew S Rifkin¹, Zhuqing Shi¹

¹Program for Personalized Cancer Care, NorthShore University HealthSystem, Evanston, Illinois, USA.

Acta obstetricia et gynecologica Scandinavica

|June 26, 2023

概括

状细胞特征 (SCT) 与不良妊娠结果 (APO) 相关,如黑人妇女的孕前和细菌性尿症. 本研究证实了这些关联,并量化了SCT对英国人口中这些APO的重大贡献.

科学领域:

生殖健康生殖健康
遗传学是一个遗传学.
公共卫生公共卫生

背景情况:

状细胞特征 (SCT) 在非洲血统的人群中很普遍.
之前的研究报告了SCT和不良妊娠结果 (APO) 之间的不一致关联.

研究的目的:

为了验证以前报告的非西班牙裔黑人妇女的SCT-APO协会.
在广泛的妊娠并发症中识别新的SCT-APO关联.
为确定APO量化SCT的可归因风险.

主要方法:

一个前性设计的英国生物银行队列的自我报告的非西班牙裔黑人女性的回顾性分析.
由HBB基因突变 (Glu6Val) 确定的SCT状态.
相对风险 (RR) 和信心区间 (CI) 调整为平价和母亲的第一个出生年龄;可归因风险比率 (ARP) 和人口可归因风险比率 (PARP) 计算.

主要成果:

在581名SCT携带者 (14.32%) 中,SCT显著与孕前 (RR 2.39) 和细菌性尿 (RR 4.85) 相关.
在携带者中,SCT占实质性风险:61%的孕前和69%的细菌性尿.
在研究人群中,孕前的可归因风险为18.3%,细菌尿的风险为24.1%. 还确定了与其他七个APO的新兴协会.

结论:

状细胞特征与英国黑人女性自我报告的特定不良妊娠结果有显著的关联.
在这个人群中,SCT在很大程度上增加了孕前和细菌性尿症的负担.
建议在独立队列中进一步验证以确认这些发现.

关键词:

常见的疾病常见的疾病.并发症可能导致并发症.糖尿病糖尿病患者糖尿病患者这种高血压,高血压.一个状细胞特征.

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