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双原子纳米酶的原子位点协同效应增强了类似过氧化酶的特性

Ruijin Zeng¹, Yanli Li¹, Xuehan Hu¹

¹Key Laboratory for Analytical Science of Food Safety and Biology (MOE & Fujian Province), State Key Laboratory of Photocatalysis on Energy and Environment, Department of Chemistry, Fuzhou University, Fuzhou 350108, P. R. China.

|June 26, 2023

概括

研究人员开发了新的单原子和双原子金属--碳纳米酶,以增强类似过氧化酶的活性. Fe1Co1-NC纳米酶表现出卓越的性能和抑制瘤生长,突出显示了纳米催化疗法的二原子协同作用.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
催化剂是一种催化剂.

背景情况:

开发有效的策略来调节纳米酶电子结构以获得卓越的催化性能至关重要.
原子分散的纳米酶具有独特的催化性能,但在设计和合成方面面临着挑战.

研究的目的:

制造和评估一个单原子和双原子金属--碳纳米酶 (M-NC) 的库,以表现出类似过氧化酶的活性.
研究双原子位点对催化性能和治疗应用的协同效应.

主要方法:

一个简单的"formamide凝结和碳化"策略被用来合成M-NC纳米酶.
评估了类似过氧酶的活性,并选择了Fe1Co1-NC纳米酶进行进一步研究.
密度函数理论 (DFT) 的计算被用来阐明电子结构和催化机制.

主要成果:

成功合成了6个单原子和13个双原子M-NC纳米酶的库.
Fe1Co1-NC双原子纳米酶由于协同Fe1-N4/Co1-N4协调,表现出最高的过氧化酶类活性.
DFT的计算证实,Co原子站点增强了Fe原子站点的电子结构,并充当了二次反应中心.

结论:

在Fe1Co1-NC纳米酶中的二原子协同作用显著增强了类似过氧化酶的活性.
Fe1Co1-NC纳米酶在抑制瘤生长方面表现出有效性,无论是体外还是体外.
这项研究确立了二原子协同作用是开发用于纳米催化疗法的先进人工纳米酶的有希望的策略.

关键词:

双原子催化剂的使用方法纳米酶是一种纳米酶.具有类似过氧酶的活性.有协同效应的效应.

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