在Helicobacter pylori相关的胃病变中,代谢物改变和与微生物群的相互作用
Lei Peng1, Yang Guo1, Markus Gerhard2,3,4
1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing, China.
Microbiology spectrum
|June 26, 2023
概括
成功根除Helicobacter pylori会显著改变代谢物,影响胃癌前病变的进展. 微生物群-代谢物相互作用是预测病变进展的关键,有助于早期风险识别.
科学领域:
- 胃肠道学和微生物学
- 代谢学和肠道微生物组研究
背景情况:
- 代谢物及其与肠道微生物群的相互作用与Helicobacter pylori感染相关的胃病变的发展有关.
- 了解这些相互作用对于预测癌前胃病变的进展至关重要.
研究的目的:
- 为了研究H. pylori根除后的代谢物变化.
- 探索微生物群-代谢物相互作用在癌前胃病变进展中的作用.
主要方法:
- 针对性代谢分析和16S rRNA基因测序在配对的胃活检样本上进行.
- 综合性分析结合了参与者成功和失败的H. pylori根除的代谢学和微生物组数据.
- 相关性分析确定了差异性代谢物和微生物一般之间的关系.
主要成果:
- 成功根除H. pylori导致81种代谢物的显著变化,包括乙卡尼丁,胺和脂质 (P <0.05).
- 不同代谢物与基线微生物群相关,Helicobacter和特定脂质之间有显著的负相关性.
- 整合代谢物,属及其相互作用的预测小组在区分病变进展高风险受试者方面表现出高准确度 (AUC 0.914和0.801).
结论:
- 代谢物和微生物群的相互作用在H. pylori相关的胃病变进展中起着重要作用.
- 开发的面板提供了一个有前途的工具,用于识别高风险发展为先进癌前病变的个体.
- 这些发现为宿主新陈代谢和胃癌发生过程中的微生物组之间的复杂相互作用提供了新的见解.
相关概念视频
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