通过向SOCS5来增强I型干扰素表达,减少了宿主对传染病病毒感染的NR2F2表达,抑制了病毒复制
Guangju You1,2,3, Wei Li1,2,3, Yongqiang Wang1,2,3
1National Key Laboratory of Veterinary Public Health Security, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Journal of virology
|June 26, 2023
概括
核受体NR2F2负面调节抗病毒免疫力. 它在感染传染病病病毒 (IBDV) 的细胞中减少表达,通过通过SOCS5.5增强I型干扰素的产生来抑制病毒复制.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 分子生物学分子生物学
背景情况:
- 核受体对于先天的抗病毒免疫力至关重要.
- 核受体在宿主对传染病病毒 (IBDV) 的反应中的作用尚不清楚.
研究的目的:
- 研究核受体亚家族2组F成员2 (NR2F2) 在宿主对IBDV感染的反应中的作用.
- 阐明NR2F2在抗病毒免疫中的潜在分子机制.
主要方法:
- IBDV感染和细胞系的多样性治疗 (DF-1,HD11).
- 对NR2F2表达水平的分析.
- 淘汰,淘汰和抑制NR2F2.2. 的作用.
- 评估病毒复制和I型干扰素/干扰素刺激基因表达.
- 对SOCS5表达的研究.
主要成果:
- 在IBDV感染或多I·C) 治疗下降NR2F2表达.
- NR2F2的淘汰/淘汰/抑制抑制了IBDV复制和增强了I型干扰素反应.
- NR2F2通过促进细胞因子信号传递5 (SOCS5) 抑制剂的表达来负面调节抗病毒免疫力.
- 减少的NR2F2通过向SOCS5来增强I型干扰素的表达,从而抑制病毒复制.
结论:
- NR2F2在抑制IBDV的抗病毒先天免疫反应方面发挥着关键作用.
- NR2F2通过调节SOCS5表达和I型干扰素的产生来负面调节IBDV感染.
- 针对NR2F2介导途径提供了IBD预防和治疗的潜在策略.
更多相关视频
07:26An Ex Vivo Chicken Primary Bursal-cell Culture Model to Study Infectious Bursal Disease Virus Pathogenesis
Published on: October 4, 2018
9.0K
06:02Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors
Published on: September 13, 2018
6.9K
相关概念视频
Regulation of Nuclear Protein Sorting
2.4K
Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
2.4K
Rous Sarcoma Virus (RSV) and Cancer
5.1K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.1K
