肝胆健康和肝胆疾病中的细胞外囊
Gopanandan Parthasarathy1, Petra Hirsova1, Enis Kostallari1
1Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Comprehensive Physiology
|June 26, 2023
概括
细胞外囊泡 (EVs) 是细胞通信和疾病的关键. 本综述详细介绍了它们在肝脏疾病中的作用,重点关注生物发生,货物和作为生物标志物和药物输送载体的治疗潜力.
科学领域:
- 细胞生物学 细胞生物学
- 纳米医学是一种纳米医学.
- 肝病学 肝病学是一种肝病学.
背景情况:
- 细胞外囊泡 (EVs) 在健康和疾病中调解细胞间通信.
- 了解EV生物发生,载荷和受体细胞的影响对于破译它们在肝脏病理中的作用至关重要.
- 目前体内研究的局限性需要在EV隔离和表征方面取得进展.
研究的目的:
- 提供最近在EV生物发生,货物,受体细胞效应和隔离/特征化方面的进展概述.
- 详细介绍EVs在肝脏疾病 (如NAFLD,病毒性肝炎和肝癌) 中的机制性作用.
- 探索电动汽车作为生物标志物和治疗输送车辆在肝胆道疾病的潜力.
主要方法:
- 关于EV生物发生,载荷选择和受体细胞效应的最新文献的综述.
- 分析使用疾病模型和人体样本进行肝脏疾病EV研究的研究.
- 讨论设计用于治疗目的的电动汽车的新方法.
主要成果:
- 详细介绍了EV生物发生机制,包括脂毒性EV和微.
- EV货物 (蛋白质,脂质,核酸) 具有特定疾病的丰富性,并赋予病原性潜力.
- EVs在NASH病变发生,HCC瘤性和化学抗药性中发挥作用.
结论:
- EVs是肝病病原和进展的关键调解者.
- 需要进一步的研究来克服技术挑战,并充分利用EV在肝病学中的诊断和治疗潜力.
- 工程电动汽车为肝脏疾病的向治疗提供了一个有希望的途径.
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