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挪威儿童青春期发育的深度表型:贝根生长研究2
Petur B Juliusson1,2, Ingvild S Bruserud2,3, Ninnie Helen Bakken Oehme2
1Department of Clinical Science, University of Bergen, Bergen, Norway.
Annals of human biology
|June 26, 2023
概括
贝尔根生长研究2使用了新的超声波方法来评估挪威儿童的青春期发育. 这项研究为乳腺发育和丸体积建立了新的参考曲线,提高了青春期分期的准确性.
科学领域:
- 儿科 儿科 儿科
- 内分泌学 在内分泌学.
- 人类成长和发展 人类成长和发展
背景情况:
- 贝尔根生长研究2 (BGS2) 调查了健康挪威儿童的体质和内分泌变化.
- 采用了一种新的方法来提高青春期发育的特征.
研究的目的:
- 在健康的挪威儿童中表征体质和内分泌变化.
- 建立新的客观超声波评估来确定青春期的阶段.
- 为关键的青春期标志物开发连续参考曲线.
主要方法:
- 2016年对1285名年龄在6至16岁的儿童进行了横截面研究.
- 利用客观超声波进行乳腺发育和丸体积评估.
- 包括传统的坦纳分期,激素测量和遗传分析.
主要成果:
- 乳腺发育的超声波分期显示了观察者之间和观察者内部的高度一致性.
- 丸体积的超声波测量显示了最小的观察者差异.
- 已确定的青春期开始的中位数年龄 (Tanner B2: 10.4年),初潮 (12.7年) 和男性青春期丸体积 (11.7年).
- 使用LMS方法开发了丸体积和性激素的连续参考曲线.
结论:
- 超声波评估为乳腺发育和丸体积提供客观可靠的数据.
- 新的参考数据允许在连续尺度上精确测量青春期的发展.
- 内分泌z分数和机器学习为分析青春期轨迹提供了先进的工具.
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