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集群头痛的过渡性侧移发作在单方面较大的尾神经注射后发生

Roemer B Brandt¹, Willemijn C Naber¹, Rosa-Lin H Ouwehand¹

¹Department of Neurology, Leiden University Medical Centre (LUMC), Leiden, the Netherlands.

|June 26, 2023

概括

集群头痛 (CH) 患者的单侧大尾神经 (GON) 注射可以暂时转移发作的侧面. 这表明涉及下丘脑路径的潜在机制,需要对双边GON注射进行进一步调查.

科学领域:

神经学神经学
疼痛医学医学疼痛医学

背景情况:

集群头痛 (CH) 发作通常是单边的,但偶尔可以交替侧面.
尚不完全了解CH攻击的侧锁机制.

研究的目的:

为了研究单边大头神经 (GON) 皮质类固醇注射在CH攻击发生侧的影响.
探索下丘脑路径在CH侧移中的潜在作用.

主要方法:

对接受单方面GON注射的七名集群头痛患者的观察.
在干预后,CH攻击发生侧面变化的记录.

主要成果:

五名先前有侧锁性CH发作的患者和两名先前有侧交替性发作的患者经历了一次过渡性的侧移,在单边GON注射后持续数周.
在所有观察到的病例中,侧移发生在注射后立即或短时间内.

结论:

单侧GON注射可能会暂时改变CH攻击的侧面,可能通过抑制双侧下丘脑攻击发生器.
对双边GON注射的进一步研究建议在单边治疗后出现侧移的患者进行进一步研究.

关键词:

一系列的案例系列.集群头痛集群头痛是指集群头痛的发生.更大的头神经注射.侧开关侧开关侧开关

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