皮层 - - thalamo - - 皮层相互作用调节电气唤起的EEG响应在小鼠
Leslie D Claar1, Irene Rembado1, Jacqulyn R Kuyat1
1MindScope Program, Allen Institute, Seattle, United States.
eLife
|June 26, 2023
概括
脑刺激复杂性分析揭示了神经电路的动态. 在小鼠中,深层皮层刺激会引起独特的休息期和反弹刺激,这对意识至关重要.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 系统神经科学 系统神经科学
背景情况:
- 扰乱复杂性分析 (PCA) 评估大脑的复杂性,以预测意识.
- 了解PCA背后的神经回路对于其临床应用至关重要.
研究的目的:
- 研究在小鼠中产生在PCA期间观察到的EEG复杂性的神经回路.
- 为了比较在清醒和麻醉期间的大脑反应.
主要方法:
- 在小鼠中进行直接皮质刺激.
- 同时进行脑电图 (EEG) 和神经像素探头记录.
- 在清醒和异氨酸麻醉期间神经活动的分析.
主要成果:
- 在清醒的小鼠中,深层皮层刺激引起了局部刺激,随后是120毫秒的"关闭"期和反弹刺激.
- thalamic核显示了类似的模式,与晚期EEG组件相关,表明皮层-thalamo-皮层参与.
- 这种"关闭"期间和反弹在移动过程中减少,并在麻醉过程中被取消.
结论:
- 在清醒状态下进行深层皮层刺激时,皮层-甲状腺-皮层相互作用对于产生长期持续的EEG信号至关重要.
- 观察到的神经动态是依赖于状态的,在运动过程中减弱,在麻醉下不存在.
更多相关视频
05:26Author Spotlight: Low-Cost Electroencephalographic Recording System Combined with a Millimeter-Sized Coil to Transcranially Stimulate the Mouse Brain In Vivo
Published on: May 26, 2023
3.7K
07:52Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents
Published on: May 23, 2025
262
相关概念视频
01:30Diencephalon: Anatomical Regions
The diencephalon, etymologically translated as 'through brain,' plays an integral role as the conduit between the cerebrum and the vast extent of the nervous system. However, the olfactory system is an exception, as it interfaces directly with the cerebrum. The diencephalon, deeply ensconced beneath the cerebrum, primarily consists of three paired structures — the thalamus, hypothalamus, and epithelamus. It also includes accessory structures such as the subthalamus, which houses the subthalamic...
01:27Diencephalon: Thalamus and Information Relay
The thalamus, often called “the gateway to the cerebral cortex,” is vital in processing and directing sensory and motor signals throughout the brain. Almost all inputs destined for the cerebral cortex, except for olfactory signals, are relayed through the thalamus. The thalamus is a sophisticated relay station, channeling information from various brain regions to the cerebral cortex, as well as a filter, prioritizing certain signals over others based on current physiological states or needs.