不同年龄段接受血液透析的ESRD患者的免疫特征
XiaoHong Chen1,2,3,4,5, FangFang Xiang1,2,3,4,5, XueSen Cao1,2,3,4,5
1Shanghai Institute of Kidney and Dialysis, Shanghai, China.
International urology and nephrology
|June 26, 2023
概括
在血液透析患者中,原始CD8+T细胞的减少与衰老有关. 这种减少预测了中年患者 (45-64岁) 的生存率,但不是年轻或老年人群.
科学领域:
- 免疫学 免疫学 免疫学
- 老年学是一门学科.
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 末期病 (ESRD) 患者接受血液透析 (HD) 显示与年龄相关的免疫变化.
- 周围T细胞子集对免疫功能至关重要,并且可能会受到HD患者衰老的影响.
研究的目的:
- 研究不同年龄段的血液透析患者的免疫特征.
- 确定与年龄相关的T细胞改变对这些患者整体存活时间的影响.
主要方法:
- 从2016年9月到2019年9月,对371名血液透析患者进行前性研究.
- 患者分为三个年龄组:<45,45-64岁和≥65岁.
- 分析T细胞亚群分布及其与整体存活率的相关性.
主要成果:
- 晚年与原始CD8+ T细胞减少和EMRA CD8+ T细胞增加有关.
- 减少的天真CD8+T细胞独立预测了贫困的3年生存率,特别是在45-64岁的年龄组.
- 在患者<45岁或≥65岁时,没有观察到对生存的显著影响.
结论:
- 周围原始CD8+T细胞的减少是血液透析患者与年龄相关的显著免疫变化.
- 这种T细胞变异是中年 (45-64岁) 血液透析患者3年整体存活期的独立预测因子.
相关概念视频
Chronic Kidney Disease I: Introduction
43
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage kidney disease (ESKD). At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate...
43
Hemodialysis I: Introduction
65
Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
65
Kidney Transplant I: Introduction
29
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
29
Hemodialysis II: Procedure and Complications
42
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
42
Hemodialysis III: Nursing Management
50
The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this...
50
Chronic Kidney Disease III: Interprofessional Care
48
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
48


