非典型抗精神病药物和D3/D2多巴胺部分激动剂卡里普拉对基于努力的选择行为的影响:对避免行为建模的影响
Alev Ecevitoglu1, Gayle A Edelstein1, Rose E Presby1,2
1Department of Psychological Sciences, University of Connecticut, Storrs, CT, USA.
Psychopharmacology
|June 26, 2023
概括
抗精神病药物卡里普拉辛在低剂量时似乎充当了D2抗剂,在动物模型中诱导了低功耗偏差. 这表明一种独特的药理方法来治疗负面症状,如精神分裂症的排斥.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 精神病学是一个精神病学.
背景情况:
- 卡里普拉辛是一种非典型的抗精神病药物,向D3/D2受体,具有治疗精神分裂症负面症状的潜力.
- 无意,一个负面的症状,以减少目标导向的行为为特征,在动物中使用基于努力的选择任务来建模.
研究的目的:
- 为了研究卡里普拉辛对动物脱落模型的基于努力的选择的影响.
- 将卡里普拉的作用与已知的D2抗剂进行比较,并探索其药理机制.
主要方法:
- 测试了与劳动力相关的选择任务 (固定比例5/食和触摸屏选择测试) 的老鼠和小鼠.
- 卡里普拉辛的作用被单独评估,并与腺氨酸A2A抗剂 (斯特拉迪菲林) 或多巴胺降低剂 (特拉贝纳辛) 结合评估.
主要成果:
- 低剂量的卡里普拉在老鼠和小鼠中诱导了低功耗偏差,减少了对高功耗选项的参与.
- 这些效应被伊斯特拉德菲林逆转,表明腺A2A受体的作用.
- 卡里普拉辛并没有抵消特拉贝纳辛的作用,这表明了类似D2的机制.
结论:
- 卡里普拉辛在动物模型中的低剂量D2家族对手作用.
- 这些发现表明,药物治疗的avolition可能不同于精神分裂症的其他负面症状.
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