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患有非功能性上腺瘤的患者的死亡率
Jekaterina Patrova1,2, Buster Mannheimer1,2, Jonatan D Lindh3
1Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
JAMA internal medicine
|June 26, 2023
概括
非功能性上腺腺瘤 (NFAA) 与较高的整体死亡率有关,包括心血管疾病和癌症导致的死亡. 这种增加的风险在被诊断为NFAA的年轻人中更为显著.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 心血管医学 心血管医学
背景情况:
- 非功能性上腺瘤 (NFAA) 是常见的上腺瘤,它们与死亡率的关联尚不清楚.
- 之前的研究对NFAA对患者存活时间的影响产生了相互矛盾的结果.
研究的目的:
- 调查非功能性上腺腺瘤 (NFAA) 与全因死亡率之间的关联.
- 确定NFAA患者的死亡原因,特别是心血管疾病和癌症.
主要方法:
- 在瑞典 (2005-2019年) 进行的一项国家回顾性基于登记册的病例控制研究中,包括17726名NFAA患者和124,366名对照患者.
- 排除标准包括上腺激素过量或癌症的诊断;随访延长至死亡或2020年底.
- 根据并发症和社会经济因素进行了调整;针对特定子组进行了敏感性分析.
主要成果:
- 与对照组相比,患有NFAA的患者整体死亡率较高 (调整后危险比率[aHR],1.21).
- 由于心血管疾病 (aHR,1.21) 和癌症 (aHR,1.54) 的死亡率在NFAA组显著增加.
- 在65岁以下的个体中,NFAA与死亡率增加之间的关联更为明显.
结论:
- 非功能性上腺腺瘤 (NFAA) 与增加全因死亡率,心血管疾病死亡率和癌症死亡率有关.
- 这些发现表明,NFAA可能是过早死亡的风险因素,特别是在年轻人群中.
- 需要进一步的研究来阐明NFAA相关死亡率的潜在机制和临床影响.
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