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在不易挥发的生物杀菌物质的泡应用过程中形成气溶
Katharina Schwarz1, Katharina Blümlein1, Thomas Göen2
1Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Nikolai-Fuchs-Str., 30625 Hannover, Germany.
Annals of work exposures and health
|June 26, 2023
概括
发泡生物制剂可以产生可吸入的气溶,造成暴露风险. 这项研究量化了泡过程中的气溶释放分数,发现值因泡技术和参数而异.
科学领域:
- 环境科学 环境科学
- 职业健康 职业健康 职业健康
- 气溶科学 气溶科学
背景情况:
- 生物杀菌产品的泡应用是用于消毒和害虫控制的滴滴喷的替代方案.
- 在发泡过程中吸入生物制剂气溶的暴露是一种潜在的风险,关于气溶生成的数据有限.
- 了解泡过程中的气溶源强度对于风险评估至关重要.
研究的目的:
- 量化生物杀菌产品泡应用过程中可吸入气溶的形成.
- 在发泡过程中确定活性物质的气溶释放分数 (ARF).
- 调查不同发泡技术中影响气溶生成的因素.
主要方法:
- 使用常见的泡技术进行了受控室实验.
- 气溶释放分数测量了机械生成的泡和使用吹气剂的泡.
- 记录了泡参数,如出口速度,喷嘴尺寸和膨胀比.
主要成果:
- 气溶释放分数在3.4 × 10−6到5.7 × 10−3 (平均值) 之间.
- 对于空气和液体泡,释放分数与泡出口速度和喷嘴尺寸等工艺参数相关.
- 泡技术显著影响了作为可吸入气溶释放的活性物质的数量.
结论:
- 发泡过程本质上产生含有活性生物杀伤剂的可吸入气溶.
- 气溶产生的程度取决于泡技术和操作参数.
- 气溶释放分量的量化对于评估与泡生物制剂相关的吸入暴露风险至关重要.
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