在COVID-19患者中的侵入性真菌病:单中心前性观察性研究
Tatjana Adzic-Vukicevic1,2,3, Milos Mladenovic2, Snezana Jovanovic2,4
1Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Frontiers in medicine
|June 26, 2023
概括
侵入性真菌病 (IFDs) 在COVID-19患者中显著增加死亡率,COVID-19相关的肺阿斯伯吉洛症 (CAPA) 和候群病 (CAC) 是最常见的. 早期诊断和治疗对于更好的结果至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 临界护理医学 临界护理医学
- 肺部病理学 肺部病理学
背景情况:
- 侵入性真菌病 (IFD) 是COVID-19患者的严重二次感染,增加了发病率和死亡率.
- 与COVID-19相关的肺炎 (CAPA) 和COVID-19相关的角膜炎 (CAC) 是观察到的最常见的IFD.
- 与较少研究的CAC相比,CAPA在COVID-19患者中发生率更高 (0.7-7.7%).
研究的目的:
- 研究住院COVID-19患者的IFD的发生率,特征和结果.
- 为了比较CAPA和CAC患者之间的临床特征和死亡率.
主要方法:
- 一项从2021年9月至12月进行的前性观察单中心研究.
- 从6,335名住院患者中,包括120名经过证明的IFD的COVID-19患者.
- 诊断通过光纤支气管镜检查,支气管支气管洗液分析,血清学和血液培养证实.
主要成果:
- 1.86%的COVID-19患者患有IFD,其中63人被诊断为CAPA,56人被诊断为CAC.
- 研究人口的平均年龄为65.7岁,患有高血压和糖尿病等共同疾病.
- 观察到高63.9%的死亡率,主要是CAC患者.
结论:
- IFD是COVID-19的严重并发症,与高死亡率有关.
- 在COVID-19患者中迅速识别和有效治疗IFD对于改善生存率至关重要.
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