渐进性皮膜黑色素瘤的临床特征和治疗结果
Milda Rancelyte1,2, Justinas Pamedys3, Ruta Grigiene4
1Clinic of Internal Diseases, Family Medicine and Oncology, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Archive of clinical cases
|June 26, 2023
概括
这一临床案例凸显了治疗转移性阴膜黑色素瘤 (UM) 的挑战. 尽管进行了多种疗法,包括放射治疗,切除,免疫治疗,化疗和向治疗,但患者的无进展和整体生存时间有限.
科学领域:
- 眼科医生 眼科 眼科
- 在瘤学瘤学.
- 医学遗传学 医学遗传学
背景情况:
- 卵巢黑色素瘤 (UM) 是一种罕见的眼睛癌症,对传统治疗反应不佳.
- 转移,主要是到肝脏,发生在50%的UM患者中,尽管初级瘤治疗.
- 化学疗法和免疫检查点抑制剂等现有疗法在UM中表现出有限的疗效.
研究的目的:
- 为了呈现一个患有转移性皮膜黑色素瘤的患者的临床病例.
- 详细介绍一个患有晚期UM的患者的治疗过程和结果.
- 讨论耐火性阴膜黑色素瘤的挑战和潜在的治疗策略.
主要方法:
- 一个单一机构的临床病例报告,一个58岁的女性患有胆管黑色素瘤.
- 治疗包括立体辐射疗法,射频废除,抗PD-1免疫疗法 (尼沃卢马布/伊皮利穆马布),达卡巴辛化疗和MEK抑制剂特拉美丁尼布.
- 通过Foundation-One®CDx进行基因组分析,为第三线治疗选择提供了信息.
主要成果:
- 患者接受了连续的息治疗,包括放射治疗,切除,免疫治疗,化疗和向治疗.
- 总生存期为28个月,从最初诊断后的无进展生存期为11个月.
- 与治疗相关的不良事件可能会影响患者的健康状况.
结论:
- 由于治疗反应不佳,转移性阴膜黑色素瘤带来了重大治疗挑战.
- 可以考虑采用多模式治疗方法,包括以基因组分析为指导的向治疗.
- 需要进一步的研究,以改善皮膜黑色素瘤患者的生存结果.
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