概括
日本食品安全委员会评估了除草剂dimesulfazet,没有发现致癌性,神经毒性或基因毒性. 最低的NOAEL导致每日可接受摄入量 (ADI) 为0.0039 mg/kg bw/day.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 食品安全 食品安全
背景情况:
- 迪梅苏尔法泽特是一种硫尼利德除草剂.
- 风险评估对于确保食品安全至关重要.
- 评估了先前关于dimesulfazet作用的研究.
研究的目的:
- 对除草剂dimesulfazet进行全面的风险评估.
- 根据毒理学数据,确定人类安全摄入水平.
- 为了确定可接受的每日摄入量 (ADI) 和急性参考剂量 (ARfD).
主要方法:
- 综述各种毒理学研究:植物和动物的命运,亚急性,慢性,生殖性,发育性和基因毒性.
- 对不良影响的分析,包括体重变化,体重和尿膀增生.
- 从所有研究中计算出最低的没有观察到不良影响水平 (NOAEL).
主要成果:
- 观察到的主要不良反应是:抑制体重增加,大鼠的脏体重增加,小鼠和狗的尿路细胞增生.
- 没有观察到致癌性,神经毒性或基因毒性.
- 从老鼠慢性毒性/致癌性研究中确定的0.39 mg/kg bw/day的最低NOAEL.
结论:
- 对于dimesulfazet,一个可接受的每日摄入量 (ADI) 为0.0039 mg/kg bw/day.
- 孕妇的急性参考剂量 (ARfD) 为0.15 mg/kg bw,一般人群的急性参考剂量为0.41 mg/kg bw.
- 在评估的水平上,dimesulfazet没有显著的致癌性,神经毒性或遗传毒性风险.
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