维生素D缺乏的患病率和与甲状腺上腺激素相关的情况
Alejandro José Ravelo Marrero1, Carlos Antonio Guillén Astete2, Miriam Menacho Román1
1Clinical Chemist, Hospital Ramón y Cajal, Madrid, Spain.
Advances in laboratory medicine
|June 26, 2023
概括
维生素D缺乏 (25-氧维生素D) 影响了近一半的成年人,男性和老年人群的患病率更高. 低维生素D水平与偏甲状腺激素 (PTH) 的升高有关.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 维生素D对骨健康和免疫功能至关重要.
- 25-氧维生素D (25-(OH) D) 是维生素D状态的主要指标.
- 副甲状腺激素 (PTH) 水平与维生素D状态密切相关.
研究的目的:
- 根据季节,性别和年龄来确定25-OH) D缺乏症的患病率.
- 调查25-OH) D水平与PTH之间的关联.
- 为了确定PTH升高的危险因素.
主要方法:
- 在2018年对33,601名患者样本进行了25-OHD测试的回顾性分析.
- 排除儿科样本和患有影响维生素D或PTH的疾病的患者.
- 统计分析包括线性和多重物流回归.
主要成果:
- 总体上,25-OH) D缺乏症的患病率为48%,男性 (53%) 比女性 (46%) 高.
- 缺乏症在最年长的年龄四分位数 (74-87岁) 中最常见,在60-73岁四分位数中最少.
- 春季显示出更高的缺陷率;夏季显示出更低的缺陷率. 低的25-OH) D与女性性别,冬季/春季季节和年龄增加的PTH (OR1.63) 相关.
结论:
- 根据性别,年龄和季节,25-OH) D缺乏症的患病率有很大差异.
- 升高的PTH主要受到低25-OH) D水平的影响.
- 女性性别,特定的季节 (冬季/春季) 和年龄较大是PTH升高的额外危险因素.
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