病例报告:在COVID-19引起的持续免疫衰竭中间歇性感染:干扰素玛是一种合适的药物吗?
Aurianne De Waard1, Laurent Lefebvre1, Julien Textoris2
1Intensive Care Unit, Centre Hospitalier Intercommunal Aix-Pertuis, Aix en Provence, France.
Frontiers in immunology
|June 26, 2023
概括
严重的COVID-19可以导致急性免疫抑郁综合征 (AIDs),导致二次感染. 干扰素玛 (IFNγ) 有效地治疗了患有艾滋病和严重COVID-19的患者,改善了单细胞功能,没有不良事件.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 关键护理医学 关键护理医学
背景情况:
- 急性免疫抑郁综合征 (AIDs) 在严重的COVID-19等关键条件下观察到.
- 艾滋病与复发的二次感染有关,使患者的康复复复杂化.
- 在COVID-19患者中,严重急性呼吸困扰综合征 (ARDS) 可以表现为长期的艾滋病.
研究的目的:
- 报告严重的COVID-19病例与长期的艾滋病.
- 评估干扰素 (IFNγ) 在治疗COVID-19患者艾滋病的疗效.
- 评估IFNγ对单细胞免疫功能的影响.
主要方法:
- 一名COVID-19患者的病例报告,患有严重的ARDS和艾滋病.
- 由于复发的二次感染而开始的联合干扰素马 (IFNγ) 治疗.
- 通过流细胞计测量免疫反应的监测,通过流细胞计测量循环单细胞的HLA-DR表达.
主要成果:
- 尽管接受了抗生素治疗,但该患者长期表现出AIDs.
- 干扰素玛 (IFNγ) 治疗导致免疫标志物的积极反应.
- 单细胞上的HLA-DR表达得到改善,表明恢复了免疫功能.
- 患者对IFNγ反应良好,没有任何不良事件.
结论:
- 严重的COVID-19可以诱导显著和持久的急性免疫抑郁综合征.
- 干扰素 (IFNγ) 是严重的COVID-19患者艾滋病的潜在治疗选择.
- IFNγ可以恢复单细胞免疫功能,并有效和安全地解决二次感染.
相关概念视频
Immunodeficiency Diseases
995
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
995
Immune Response Against Viral Pathogens
830
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
830
Pulmonary Tuberculosis I
286
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
286
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
201
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
201
Factors Affecting the Risk of Infection
12.0K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.0K
Myocarditis III: Medical Management
9
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
9


