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来自植物的特殊代谢物作为新型多向抗病毒药物的来源:系统性审查

Maria Ponticelli¹, Maria Laura Bellone^2,3, Valentina Parisi^2,3

¹Department of Science, University of Basilicata, Viale Dell'ateneo Lucano 10, 85100 Potenza, Italy.

Phytochemistry reviews : proceedings of the Phytochemical Society of Europe

|June 26, 2023

概括

植物提供天然抗病毒化合物,通过抑制病毒的进入和复制来对抗病毒感染. 本综述总结了植物性代谢物及其对抗病毒的机制,为传统药物提供了替代品.

科学领域:

* 植物化学和病毒学
* * 自然产品化学自然产品化学

背景情况:

* 病毒感染构成了全球重大健康挑战,现有的抗病毒药物往往会引起不良反应并导致病毒耐药性.
*植物是一种丰富的特殊代谢物来源,具有已证明的抗病毒特性,提供潜在的治疗替代品.
*植物化学物质可以通过干扰病毒进入宿主细胞和细胞内信号通路来抑制病毒复制.

研究的目的:

*系统地审查植物来源的特殊代谢物的体内抗病毒活性.
* 阐明这些植物性化合物发挥抗病毒作用的作用机制.
* 巩固当前关于植物性抗病毒药物的知识,以潜在的治疗应用.

主要方法:

*对研究植物提取物和分离代谢物的体内抗病毒活性进行系统性文献综述.
*分析报告的作用机制,包括抑制病毒进入,复制和调节宿主细胞通路.
*专注于专门的代谢物,如黄类,类,类,类和类.

主要成果:

* 许多植物性特种代谢物在体内对一系列病毒表现出显著的抗病毒活性.
*这些化合物通过多种机制起作用,包括阻断病毒的附着和进入,抑制病毒复制酶,调节宿主免疫反应.
* 某些特定的植物化学物质,如黄类和类,经常被认为是强大的抗病毒药物.

结论:

*植物衍生特种代谢物是开发新型抗病毒疗法的有希望的来源.
*了解它们的作用机制对于优化它们的治疗潜力和克服耐药性至关重要.
*对植物性抗病毒药物的进一步研究可能会导致对病毒感染的更安全,更有效的治疗方法.

关键词:

抗病毒活性具有抗病毒活性.抗病毒药物的作用机制在生物体内进行的研究.天然化合物是一种自然化合物.系统性审查系统性审查

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