作为一种自我微乳化药物输送系统的梅洛西卡姆的配方和体外评估
Saja Abdulkareem Muhammed1, Khalid Kadhem Al-Kinani1
1Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad, Baghdad Governorate, Iraq.
F1000Research
|June 26, 2023
概括
这项研究开发了一种液体自我微乳化药物输送系统,以提高梅洛西卡姆 (MLX) 的分散性和稳定性. 优化的配方表现出卓越的药物释放和稳定性,为MLX输送提供了一种实际的解决方案.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 纳米技术纳米技术
背景情况:
- 墨洛西卡姆 (MLX) 是一种氧卡姆类非抗氧化剂,具有较差的水溶性,限制了其治疗功效.
- 提高像MLX这样的难溶性药物的分散性和稳定性,对于有效的药物输送至关重要.
- 液体自微乳化药物递送系统 (SMEDDS) 是一种有前途的方法,可以提高疏水性药物的可溶性和生物可用性.
研究的目的:
- 制定和表征一种液体自我微乳化药物输送系统 (SMEDDS) 用于梅洛西卡姆 (MLX).
- 通过使用一种新的SMEDDS配方来提高梅洛西卡姆的分散性和稳定性.
- 评估优化MLX载荷SMEDDS的物理化学特性和体外性能.
主要方法:
- 开发了五种不同的液体SMEDDS配方,使用不同度的烯基醇,Transcutol P,Tween 80和油酸.
- 构建一个伪三元相位图来识别微乳液区域.
- 评估配方的热力学稳定性,滴滴大小,多分散性指数 (PDI),泽塔潜力,药物含量,分散性和体外药物释放.
主要成果:
- 最佳配方 (F5) 呈现出高药物含量 (99.8%) 和优异的体外释放 (100%在40分钟内).
- F5 显示了小滴体大小 (63 nm),低 PDI (0.3) 和高稳定性,由 -81 mV 的 zeta 潜力表明.
- 开发的SMEDDS配方显示出良好的热力学稳定性和耐稀释性.
结论:
- 液体自我微乳化药物输送系统在改善梅洛西卡姆的分散性和稳定性方面非常有效.
- 优化的SMEDDS配方提供了一种可行和实用的方法,用于增强MLX等水溶性较差的药物的输送.
- 这项研究突出了SMEDDS克服可溶性挑战并改善现有药物的治疗结果的潜力.
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