生物心理社会因素与大脑年龄的关联:一项大规模的英国生物库扩散研究,对35,749名参与者进行了研究

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Max Korbmacher^1,2,3, Tiril P Gurholt², Ann-Marie G de Lange^2,4,5

¹Department of Health and Functioning, Western Norway University of Applied Sciences, Bergen, Norway.

Frontiers in psychology

|June 26, 2023

概括

根据大脑特征预测的大脑年龄,与健康结果有关. 生物心理社会因素解释了一些,但不是所有,大脑年龄差异,突出了进一步研究的需要.

科学领域:

神经成像是一种神经成像.
生物标志物生物标志物
衰老研究研究衰老研究

背景情况:

由大脑特征预测的大脑年龄,是一般健康的潜在生物标志物.
以前的研究没有从扩散MRI数据系统地评估大脑年龄的变化.
了解影响大脑年龄的因素对于衰老研究至关重要.

研究的目的:

使用扩散MRI数据开发大脑年龄的多变量模型.
研究大脑年龄与生物心理社会变量之间的关系.
评估社会人口结构,认知和生活方式因素对大脑年龄的影响.

主要方法:

从单个和多扩散MRI数据对大脑年龄的多变量建模.
分析大脑年龄与社会人口统计学,认知,生活满意度,健康和生活方式因素的关联.
大型样本 (N=35,749) 从中年到老年 (44.6-82.8岁).

主要成果:

生物心理社会因素解释了在扩散方法中大脑年龄差异的一小部分.
认知得分,生活满意度和健康/生活方式因素有助于解释差异,与社会人口统计学不同.
对于腰部至部比率,糖尿病,高血压,吸烟,认知任务和满意度指标发现了一致的关联.
观察到大脑年龄的性别和种族群体差异的显著变化.

结论:

大脑年龄不仅仅是由生物心理社会变量来解释的.
协会建议在未来的大脑年龄研究中调整性别,种族,认知和健康/生活方式因素.
建议研究生物心理社会因素与大脑年龄之间的相互作用.

关键词:

年龄预测年龄预测大脑年龄大脑年龄大脑的可变性大脑的变化.认知认知认知扩散磁力共振成像 (MRI) 扩散医疗保健医疗保健医疗保健磁共振成像技术的使用

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