在晚期结肠直肠癌中双向化疗 腹膜转移 腹膜转移
Ambarish Chatterjee1, Mufaddal Kazi1, Vikas Ostwal2
1Unit of Colorectal and Peritoneal Surface Malignancy, Department of Surgical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Dr. E Borges Road, Parel, Mumbai, 400 012 India.
带有全身化疗的腹腔内帕克利塔塞尔是患有腹腔转移的结直肠癌患者的安全和可行的治疗方法,没有严重的不良事件,并提供潜在的临床益处.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
背景情况:
- 结肠直肠癌 (CRC) 具有广泛的腹转移,对患者的预后不佳,无法接受超热腹内化疗 (CRS-HIPEC) 的细胞还原性手术.
- 评估替代治疗策略对于改善这一患者群体的治疗结果至关重要.
研究的目的:
- 评估系统性和腹膜内 (IP) 帕克利塔塞尔化疗在患有腹膜转移的CRC患者中的可行性,安全性和临床反应.
- 为了确定与IP化疗通过化疗输送相关的耐受性和术后并发症.
主要方法:
- 一项前性研究,涉及确诊腹转移的CRC患者.
- 患者在IP化疗移植后每周接受IP帕克利塔塞尔 (20 mg/m2) 与全身化疗.
- 主要终点包括可行性,安全性和耐受性;次要终点是临床放射学反应.
主要成果:
- IP化疗移植成功植入了18名患者,其中14人接受了IP化疗.
- IP化疗周期的中位数为3.5;由于并发症,14.3%的患者需要进行化疗移植切除.
- 临床放射学反应包括4名患者的部分反应,5名患者的疾病稳定,3名患者的疾病进展. 没有观察到3-5级并发症.
结论:
- 增量剂量IP帕克利塔塞尔与全身化疗相结合,对于某些患有腹膜转移的CRC患者来说是安全的和可行的.
- 这种方法证明了良好的安全性,没有严重的不良事件,为不适合CRS-HIPEC的患者提供了可行的选择.
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