在临床实践中实施LESS-CHRON的可行性:在多病症老年患者中进行试点干预研究
Marta Mejías-Trueba1,2, Aitana Rodríguez-Pérez1, Carlos Hernández-Quiles3
1Department of Pharmacy, University Hospital Virgen del Rocio, Seville, Spain.
Innovation in aging
|June 26, 2023
概括
基于证据的慢性病患者处方停止清单 (LESS-CHRON) 标准可用于识别老年人潜在不合适的药物 (PIM). 这项试点研究表明,成功地降低了抑郁症和降低了抗胆固醇负担,尽管临床结果需要进一步调查.
科学领域:
- 老年医学 老年医学
- 药理学 药理学是指药理学的学科.
- 临床药房 临床药房
背景情况:
- 潜在不合适的药物 (PIMs) 对老年人构成风险.
- 降低处方是一种优化药物治疗的策略.
- 慢性病患者的证据为基础的抑郁症列表 (LESS-CHRON) 标准旨在系统化抑郁症.
研究的目的:
- 评估在老年多病患者的临床途径中实施LESS-CHRON标准的可行性.
- 评估抑郁症治疗干预措施对药物治疗方案和患者结果的影响.
主要方法:
- 进行了一项前后准实验性试点研究.
- 包括具有多种疾病的老年门诊患者.
- 可行性是通过药剂师推的药物治疗干预措施的应用概率来衡量的.
主要成果:
- 实施可行性为45.3% (43/95报告进行了评估).
- 根据LESS-CHRON标准确定了92个PIM,接受率为76.7%.
- 在3个月后,82.7%的患者保持了成功的抑郁,抗胆固醇负担减少,坚持改善.
结论:
- 在护理途径中实施 LESS-CHRON 标准是可行的.
- 这项干预措施表现出良好的接受度和成功的抑止处方.
- 需要进行更大规模的研究来确认对临床和医疗保健利用变量的影响.
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