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Updated: Jul 25, 2025

In Silico Clinical Trials for Cardiovascular Disease

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一个系统的审查心脏在的临床试验

Cristobal Rodero^1,2,3, Tiffany M G Baptiste^1,2, Rosie K Barrows^1,2

¹Cardiac Electro-Mechanics Research Group (CEMRG), National Heart and Lung Institute, Imperial College London, London, United Kingdom.

Progress in biomedical engineering (Bristol, England)

|June 26, 2023

概括

计算式心脏模型,或in-silico临床试验 (ISCTs),正在推进心脏病学. 然而,一项系统性审查显示,患者数据,验证和模型共享的报告不一致,这突显了对心脏ISCT标准化实践的需求.

科学领域:

心脏病学心脏病学
计算生物学计算生物学
医疗信息学医疗信息学

背景情况:

计算模型越来越多地用于心脏病学中的in-silico临床试验 (ISCT).
随着ISCT的普及,建立方法报告和分析的最佳实践至关重要.

研究的目的:

评估心脏ISCTs的类型,分析方法和报告标准.
确定心脏ISCTs当前实践中的差距和改进领域.

主要方法:

对2012年1月1日至2022年1月1日期间发表的心脏ISCT进行了系统审查.
研究集中在人类患者队列上,不包括单个个体研究或没有对照组的研究.

主要成果:

确定了36个心脏ISCT出版物,主要来自美国和英国.
在部分研究中报告了验证,但报告患者人口统计,不确定性量化和数据/模型共享是不一致的.
最常见的软件是 ANSYS FLUENT,尽管经常没有报道.

结论:

对于患者人口统计,队列质量控制和心脏ISCT中的不确定性量化,需要社区同意的最低报告标准.
增加模型和数据的共享对于ISCT在心脏病学中的进步和可重复性至关重要.

关键词:

计算心脏病学计算心脏病学计算试验试验试验试验试验数字双胞胎数字双胞胎是什么意思心脏模拟心脏模拟器虚拟临床试验是虚拟的临床试验.

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Clinical Trials

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...