不恰当的出生体重对新生儿的新生儿存活率的负担:一个以人口为基础的研究在中等收入环境中进行
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Updated: Jul 25, 2025

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Biochemical Measurement of Neonatal Hypoxia
Published on: August 24, 2011
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Tulio Konstantyner1, Kelsy Catherina Nema Areco1,2, Paulo Bandiera-Paiva2
1Departamento de Pediatria, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil.
Frontiers in pediatrics
|June 26, 2023
概括
新生儿死亡风险显著高于孕期婴儿,其出生体重与妊娠年龄 (VSGA) 相比非常小. 通过产前护理解决胎儿生长限制问题,可以降低新生儿死亡率,特别是在发展中国家.
科学领域:
- 新生儿科学 新生儿科学
- 围产期流行病学 围产期流行病学
- 公共卫生 公共卫生
背景情况:
- 过早分娩,围产期窒息和感染是新生儿死亡的主要原因.
- 出生时的生长偏差,特别是在发展中国家,会影响新生儿的生存率.
- 不适当的出生体重是新生儿后果的一个关键因素.
研究的目的:
- 为了调查出生时不适当的体重和新生儿死亡之间的关系,在生产期的新生儿中.
- 量化与妊娠年龄非常小 (VSGA) 和妊娠年龄非常大 (VLGA) 婴儿相关的死亡风险.
主要方法:
- 在巴西圣保罗州 (2004-2013) 实时活产的观察后续研究.
- 出生和死亡证明的数据链接.
- 定义VSGA和VLGA使用Intergrowth-21st百分位数;使用Kaplan-Meier和Cox回归分析新生儿死亡率 (0-27天).
主要成果:
- 新生儿死亡率为12.03/10,000活产婴儿.
- 1.8%的新生儿是VSGA,2.7%的新生儿是VLGA.
- 不管其他因素如何,VSGA婴儿的死亡风险明显增加 (调整HR=4.25).
结论:
- 预产期婴儿的出生体重限制增加了新生儿死亡风险大约四倍.
- 有针对性的产前护理策略来管理胎儿生长限制对于降低巴西和类似环境中的新生儿死亡率至关重要.
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