可见光和NIR光光激活基胺系统,用于高效的药物释放,具有光监测
Ajay Gupta1, Neelu Singh1, Aryan Gautam1
1School of Physical Sciences, Jawaharlal Nehru University New Delhi 110067 India pijus@mail.jnu.ac.in.
RSC medicinal chemistry
|June 26, 2023
概括
研究人员使用o-hydroxycinnamate开发了新的可光激活的前药物. 这些前药物能够控制药物释放和实时监测可见光或NIR光,为先进的癌症疗法提供潜力.
科学领域:
- 生物医学工程 生物医学工程
- 有机化学 有机化学
- 摄影化学的使用.
背景情况:
- 可光激活保护组 (PPG) 对于控制生物医学中的分子活性至关重要.
- 通过可见/红外光激活的PPG与光监测的开发仍然是一个挑战.
研究的目的:
- 用可见光和红外线光激活的基于o-hydroxycinnamate的PPG来制造可控的药物释放.
- 为了实现实时监测药物释放使用光.
主要方法:
- 合成了一种可光激活的前药物,通过将可光移动的o-hydroxycinnamate组连接到gemcitabine.
- 使用可见光 (一光子) 和NIR (两光子) 光来激活前药物.
- 量化药物释放通过监测库马林记者光.
- 使用FACS和光显微镜研究细胞吸收和局部化.
主要成果:
- 这种基于o-hydroxycinnamate的前药物在可见光和NIR光照射时表现出有效的药物释放.
- 一个光库马林记者允许实时监控药物释放.
- 前药物被癌细胞有效吸收并定位在线粒体中.
- 观察到光触发,剂量依赖和时间控制的癌细胞死亡.
结论:
- 开发了一种新的可光激活的前药物系统,用于控制药物输送和释放.
- 证明了基于o-hydroxycinnamate的PPG在可见光和NIR光激活疗法的潜力.
- 该系统提供实时监控功能和有针对性的细胞效应,为先进的生物医学应用铺平了道路.
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