血液恶性瘤患者感染死亡率的趋势:根据血液恶性瘤亚型的差异
Xuejiao Yin1,2, Xuelian Hu3,2, Hongyan Tong4,2
1Department of Hematology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Therapeutic advances in chronic disease
|June 26, 2023
概括
一些白血病和淋巴瘤的感染特异性死亡率下降,但在其他情况下增加. 男性性别,年龄较大和黑人种族是癌症患者感染死亡率的不良预后因素.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 感染是血液恶性瘤患者的主要死亡原因,增加医疗保健费用和住院时间.
- 这些患者感染特异性死亡率 (ISM) 趋势的综合数据有限.
研究的目的:
- 分析血液瘤患者中ISM的最新趋势.
- 在这个患者群体中确定与增加ISM相关的因素.
主要方法:
- 来自监测,流行病学和最终结果 (SEER) 数据库 (1983-2016) 数据的回顾性分析.
- 包括五种常见的血液性恶性瘤患者.
- 应用联合点回归来评估死亡率趋势.
主要成果:
- 从1983年起,急性白血病 (AL),霍奇金淋巴瘤 (HL) 和非霍奇金淋巴瘤 (NHL) 的ISM下降.
- 从2000年开始,慢性白血病 (CL) 和多发性骨髓瘤 (MM) 的ISM显著增加.
- 在男性中观察到更高的ISM率,男性性别,年龄较大,黑人种族和未婚状态被确定为不良预后因素.
结论:
- 虽然一些血液性恶性瘤显示ISM下降,但CL和MM显示有关增加.
- 风险评估和警的感染监测对于血液恶性瘤患者至关重要,特别是那些患有CL和MM的患者.
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