美国全国代表性样本中的环境暴露和心血管疾病 成人
Joshua Cheek1,2, Sara Shuger Fox1, Hans-Joachim Lehmler3,4
1Department of Kinesiology, Central College, Pella, IA USA.
Exposure and health
|June 26, 2023
概括
环境暴露与美国成年人心血管疾病 (CVD) 有关. 这种联系是非单调的,这意味着更高的含量并不总是与心血管疾病风险增加相关.
科学领域:
- 环境健康 环境健康
- 心血管疾病研究研究
- 毒理学 毒理学 毒理学
背景情况:
- 实验室研究表明,和心血管疾病 (CVD) 发病之间的联系.
- 然而,证实这种关联的人类观测数据仍然有限.
研究的目的:
- 在美国成年人群中调查环境暴露与心血管疾病之间的横截面关联.
- 用尿中的度作为暴露的生物标志物.
主要方法:
- 在国家健康和营养检查调查 (2017-20) 中分析了来自2702名美国成年人的数据.
- 根据心脏病发作,胸痛,冠状动脉疾病或中风的自我报告诊断而定义的CVD.
- 使用物流回归与样本重量来评估尿水平与心血管疾病患病率之间的关系.
主要成果:
- 与没有心血管疾病的人 (1.08μg/L) 相比,患有心血管疾病的人的尿度中位数 (1.34μg/L) 更高.
- 调整后的几率比率表明,在尿的较高四分位数中,心血管疾病风险增加.
- 在暴露和心血管疾病之间发现了一个非单调的,反向的U形关联 (P < 0.001).
结论:
- 暴露与美国成年人的心血管疾病有显著的关联.
- 这种关系是非单调的,独立于已确定的心血管疾病风险因素.
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