状细胞在过敏性鼻炎中表达出一种由大脑衍生的神经营养因子的新模式
Li Fang1,2, Chun-Hao Li1,3, Qian Zhang1,3
1Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, People's Republic of China.
Journal of inflammation research
|June 26, 2023
概括
大脑衍生神经营养因子 (BDNF) 的表达在过敏性鼻炎的状细胞中减少,但在过敏原暴露后暂时增加. 这种局部变化可能解释了过敏性鼻炎期间鼻洗液中BDNF的升高.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 过敏研究 研究过敏
背景情况:
- 大脑衍生神经营养因子 (BDNF) 与过敏性疾病中的神经过敏反应和呼吸道抵抗有关.
- 在鼻洗液 (NAL) 中观察到BDNF水平升高,但其在过敏性鼻炎患者的状细胞中的存在尚不清楚.
研究的目的:
- 研究过敏性鼻炎 (AR) 患者的纤毛细胞中BDNF的表达和局部化.
- 在AR的小鼠模型中,探索BDNF在毛细胞和生物流体中的动态变化.
主要方法:
- 来自AR患者和小鼠的鼻腔粘膜细胞的免疫光染色.
- 用RT-PCR检测BDNF和IL-4/5/13的表达.
- 通过ELISA测量BDNF,总IgE,以及血清和NAL液体中的卵蛋白特异IgE.
主要成果:
- 与对照组相比,AR患者在纤毛细胞中的BDNF表达显着较低,与症状严重程度 (VAS得分) 有负相关.
- 在小鼠模型中,血清和NAL液体中的BDNF水平在过敏原挑战后暂时增加.
- 细胞BDNF在小鼠中最初增加,然后在过敏原暴露后减少.
结论:
- 这项研究首次证明了BDNF表达和局部化在过敏性鼻炎中的人类鼻皮质细胞中.
- 持续的过敏性鼻炎与纤毛细胞中BDNF表达的减少有关.
- 在过敏原刺激后,状细胞中BDNF的暂时增加可能会导致血清和NAL液体中BDNF的升高.
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