识别虚拟现实的应用,使得中风翻译管道受益
Matan Bone1, Maham Malik1, Siobhan Crilly2,3
1School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre and The University of Manchester, Manchester, UK.
Brain and neuroscience advances
|June 26, 2023
概括
虚拟现实 (VR) 可以通过生成从受伤到恢复的标准化数据来改善中风研究. 这种方法提高了临床前发现的可靠性,可能导致更好的中风管理疗法.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 康复科学 康复科学 康复科学
背景情况:
- 脑卒中是导致死亡和残疾的主要原因,尽管进行了广泛的研究,但药物治疗选择有限.
- 在中风研究中的一个重大挑战是翻译差距,临床前发现往往无法在临床环境中复制.
研究的目的:
- 审查适用于临床前和临床中风研究的虚拟现实 (VR) 技术.
- 探索VR在量化神经系统结果和改善中风康复方面的潜力.
- 为更可靠的中风管理研究提出VR增强的反翻译策略.
主要方法:
- 审查关于VR在神经疾病和中风康复中的应用现有文献.
- 讨论VR如何量化临床结果和患者康复.
- 建议将VR纳入中风研究的反转译文框架.
主要成果:
- 虚拟现实技术可以量化神经疾病的临床结果,并有可能应用于中风.
- 沉浸式VR程序可以标准化和量化中风损伤严重程度和患者康复.
- 通过VR进行持续,标准化的数据生成可以弥合临床前和临床中风研究之间的差距.
结论:
- 虚拟现实提供了一种新的方法来增强对中风损伤和恢复的理解.
- 在中风研究中实施VR可以通过反向翻译策略提高临床前发现的可靠性.
- 这种综合方法可以加速将有效的中风管理方案和药物转化为临床实践.
相关概念视频
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Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Translation
Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Improving Translational Accuracy
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are called the...
Translation Produces the Building Blocks of Life
Proteins are called the...


