与COVID-19或SARS-CoV-2疫苗接种相关的补充介导的血栓性微血管病变
Christof Aigner1, Martina Gaggl1, Sophie Schmidt1
1Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Kidney international reports
|June 26, 2023
概括
与SARS-CoV-2疫苗接种相比,COVID-19感染对非典型的血溶性尿素性综合征/补充介导的血栓性微血管病变 (aHUS/cTMA) 复发的风险更高. 在COVID-19或接种疫苗后,aHUS/cTMA的总体发病率仍然很低.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
背景情况:
- 传染病和疫苗接种可以引发血栓性微血管病变 (TMA).
- COVID-19大流行可能会影响非典型的血液溶解综合征/补充介导的血栓性微血管病变 (aHUS/cTMA) 的表现或复发.
研究的目的:
- 为了调查COVID-19感染或SARS-CoV-2疫苗接种后aHUS/cTMA复发的发生率.
- 为了比较COVID-19感染和SARS-CoV-2疫苗接种之间的aHUS/cTMA复发风险.
主要方法:
- 使用维也纳TMA队列数据库来获取患者数据.
- 分析了发病率,并使用了Cox比例危险模型来比较感染或接种疫苗后的HUS/cTMA发作.
主要成果:
- 13种感染引发了3 (23%) 的TMA发作,而70种疫苗引发了1 (1%) 的TMA发作.
- 在COVID-19或疫苗接种后的TMA发生率为每100个患者年中有6例.
- 在2012年至2022年期间,没有观察到aHUS/cTMA发病率显著增加.
结论:
- 与SARS-CoV-2疫苗接种相比,COVID-19感染与aHUS/cTMA复发的风险更高有关.
- 在COVID-19感染或接种疫苗后,aHUS/cTMA的发生率很低,并且与现有的文献一致.
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