基于微室膜药物封装的药物排泄三明治水凝镜片
Valeriya Kudryavtseva1,2, Mariana Otero1, Jiaxin Zhang3
1School of Engineering and Materials Science, Queen Mary University of London, London E1 4NS, U.K.
ACS nanoscience Au
|June 26, 2023
概括
这项研究引入了一种新型的隐形眼镜,可以在治疗眼睛炎症时提供皮质类固醇. 创新的水凝透镜提供持续的药物释放,改进了传统的眼滴治疗方法.
科学领域:
- 眼科医生 眼科 眼科
- 材料科学 材料科学 材料科学
- 药物输送系统 药物输送系统
背景情况:
- 皮质类固醇对于控制眼部炎症至关重要.
- 目前的眼滴输送方法往往不方便和低效,导致潜在的副作用.
- 需要改善眼科治疗的药物输送系统.
研究的目的:
- 开发和验证一种基于隐形眼镜的药物输送系统,用于皮质类固醇的概念验证.
- 为了在水凝隐形眼镜中创建德克萨梅他的持续和受控释放机制.
- 为了保证隐形眼镜设计中保持视觉清晰度.
主要方法:
- 使用软光刻法制造一种三明治水凝隐形镜片,其中包含一个聚合物微室膜.
- 在隐形眼镜的微室内封装德克萨米他.
- 从镜头的中央视觉区域移除微室材料.
主要成果:
- 开发的隐形眼镜显示了德克萨米他的持续和受控释放.
- 该系统成功地将药物输送能力集成到隐形眼镜格式中.
- 中央孔口保持清晰,保持视觉功能.
结论:
- 一种基于隐形眼镜的新型皮质类固醇药物递送系统已经成功开发出来.
- 这种创新方法为治疗眼部炎症的传统眼滴提供了一个有希望的替代方案.
- 该系统提供持续的药物释放,并保持视觉清晰度,增强患者的服药性和治疗结果.
相关概念视频
01:19Modified-Release Drug Delivery Systems: Rate-Programmed II
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
01:23Ophthalmic Drug Delivery Systems
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...