蒙古的SARS-CoV-2血清流行病学,2020-2021年:一个纵向的国家研究
Battogtokh Chimeddorj1,2, Christopher R Bailie3, Undram Mandakh4
1Department of Microbiology and Infection Prevention Control, School of Biomedicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.
The Lancet regional health. Western Pacific
|June 26, 2023
概括
由于疫苗接种和感染,蒙古在2021年底 SARS-CoV-2 血清流行率显著上升. 截至年底,超过82%的人表现为血清阳性,在未接种疫苗的人群中感染率高.
科学领域:
- 流行病学 流行病学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- COVID-19大流行对发展中国家的影响仍未得到充分研究.
- 蒙古在2020年初实施了严格的控制措施,推迟了广泛传播,直到2021年2月疫苗可用.
- 该研究调查了2020-2021年在蒙古的SARS-CoV-2血清流行及其决定因素.
研究的目的:
- 在蒙古人口中追踪SARS-CoV-2血清标记.
- 为了确定分布和影响血清流行的因素.
- 评估疫苗接种率和以前的感染率,在疫情的背景下.
主要方法:
- 使用世卫组织的统一研究协议进行长度血清流行病学研究.
- 数据收集来自5000个人四轮 (2020年10月 - 2021年12月) 的数据.
- 年龄分层的多阶段集群采样,抗体检测 (总体,IgG,中和) 和与国家注册表的联系.
主要成果:
- 血清流行率从2020年底的1.5%升至2021年底的82.3%.
- 到2021年底,疫苗接种率达到62.4%;64.5%的未接种疫苗的人被感染.
- 卫生工作者显示,确诊COVID-19的几率更高;男性和20岁以上的成年人有更高的血清转化几率.
结论:
- 蒙古在2021年由于疫苗接种和感染,血清阳性迅速增加.
- 到2021年底,观察到高血清流行率,但Omicron变种引发了重大流行病.
- 这项研究强调了SARS-CoV-2传播的动态性质和发展中国家背景下的血清学反应.
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